Genetic stability maintenance
requires an extremely accurate mechanism for DNA replication and
mechanisms for fixing the several accidental lesions that occur continually in
DNA. Spontaneous changes in DNA are temporary
due to immediate correction process called DNA repair. DNA repair’s importance
is very evident from the huge investment that cells form in DNA repair enzymes.
In 1000 accidental base changes in DNA , fewer than one results in a permanent
mutation due to the efficient elimination by the DNA repair.
